Endocrine Abstracts

The high-density lipoprotein (HDL) levels are decreased in paitents with hypogonadotropic hypogonadism (HH). Although testosteron regulates lipoprotein metabolism, the effect of testosterone replacement therapy on HDL metabolism is not clearly shown in HH. The aim of this study is to determine the effects of testesterone replacement on HDL subfractions in young patients with HH. Forty-three cases with HH (mean age 21±2.45 years) were enrolled. Fifty-one healthy volunteer ...

Obesity is a risk factor for calcaneal spur (CS) formation which is supposed to originate from chronic plantar fasciitis. But histological findings support the thesis that ‘plantar fasciitis’ is a degenerative fasciosis without inflammation. Diabetes mellitus may contribute to the risk of CS by decreased ability of tissue repair and increased reactive ossification. Thus, we aimed to determine CS incidence in asymptomatic obese subjects with and without type 2 diabete...

Objective: One of the common features of hypothyroidism is weight gain or failure to lose weight. Also bradycardia and mild hypertension can be seen. Impact of thyroid hormone deficiency on glucose and insulin metabolism is not fully understood. Thyroid hormones play role in lipid synthesis, metabolism and mobilization. Metabolic syndrome is a state which most features of hypothyroidism can be seen. Our aim is to investigate the frequency of metabolic syndrome in hypothyroid p...

Objective: Thyroid hormones directly or indirectly, through erythropoietin, stimulate growth of erythroid colonies. Anemia is often the first sign of hypothyroidism. Hypothyroidism can lead to a wide variety (%20–60) of anemic disorders. Numerous mechanisms are involved in the pathogenesis of these anemias which can be microcytic, macrocytic and normocytic. Microcytic anemia is usually ascribed to malabsorption of iron and loss of iron by menorrhagia. Macrocytic anemia is...

Background: Diabetic foot ulcer and lower extremity amputation are leading causes of mortality and morbidity in diabetic patients. Diabetic neuropathy and peripheral vascular disease are major reasons for diabetic foot ulcer. Most of the studies showed that hyperhomocystinemia is related with microvascular and macrovascular complications in diabetic patients. Also hyperhomocysteinemia is related to poor ulcer healing. In this study, we investigated the relationship of hyperhom...

Objective: Diabetic foot ulcer is associated with increased morbidity and mortality. The most important factor related to the development of foot ulcer is peripheral neuropathy. Thrombin-activatable fibrinolysis inhibitor (TAFI) is associated with coagulation, fibrinolysis and inflammation. Plasma TAFI may participate in arterial thrombosis in cardiovascular diseases (CVD). TAFI may be involved in the mechanism of vascular endothelial damage in diabetic patients. The aim of th...

Liquid Chromatography tandem mass spectrometry (LC–MS/MS) is gold-standard for androgen analysis in biological fluids, superseding immunoassays in specificity, particularly at low concentrations. While LC–MS/MS is well established for analysis of testosterone (T) and androstenedione (A4), 5α-dihydrotestosterone (DHT) presents greater analytical challenges. DHT circulates at low nanomolar concentrations in men and lower in women, ionising inefficiently. Thus, eve...

Introduction: Intensive insulin treatment in obese patients with type 2 diabetes (T2DM) is often difficult. Insulin dosages are much higher, which further increase weight gain and the risk of hypoglycemia. Glucagon like peptide 1 receptor agonists (GLP-1RAs) are the promising treatment modalities causing weight loss and reducing the risk of hypoglycemia. There is no published data about the effect of adding on GLP1RAs to obese T2DM patients with un-controlled glucose levels un...

Hypogonadism is associated with increased body fat content and insulin resistance. Many associations including ADA, IDF and EASD declare that waist circumference is a reliable measure of visceral adiposity and may account for insulin resistance. Our observations in young male patients with idiopathic hypogonadotrophic hypogonadism (IHH) are opposite. Thus, we aimed to compare body fat content and anthropometric measurements between patients and age-matched eugonadal healthy co...

Background: Idiopatic hypogonadotropic hypogonadism is a congenital abnormality due to GnRH deficiency which is associated with severe osteoporosis. Testosterone replacement has been shown to improve the loss in the bone mass. The aim of the present retrospective analysis was to measure the effect of human chorionic gonadotropin treatment on the improvement of bone mineral density.Methods: A total number of 96 young male (mean age 21±3.7 years) pati...